Abstract
BackgroundAdipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. This study therefore aimed to examine whether associations exist between adipokines gene polymorphisms and knee OA by considering the evidence collected from eligible studies through a meta-analysis.MethodsA systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on the associations between adipokines gene polymorphisms and knee OA with the allele model, dominant model, and recessive model.ResultsThe present meta-analysis included 5 eligible studies for ADIPOQ rs1501299 with 1,021 cases and 1,097 controls, 3 eligible studies for ADIPOQ rs2241766 with 549 cases and 544 controls, 3 eligible studies for LEPR rs1137101 with 808 cases and 856 controls, 2 eligible studies for VISFATIN rs4730153 with 339 cases and 680 controls and 2 eligible studies for VISFATIN rs16872158 with 339 cases and 680 controls. Significant association was observed between LEPR rs1137101 and knee OA in the overall population (recessive: OR = 0.40, 95% CI 0.21–0.79). Limited data revealed that associations may exist between ADIPOQ rs2241766 and knee OA in Asians (dominant: OR = 1.35, 95% CI 1.03–1.78), between VISFATIN rs4730153 and knee OA in Asians (allele: OR = 0.58, 95% CI 0.41–0.83; dominant: OR = 0.57, 95% CI 0.39–0.83), and between VISFATIN rs16872158 and knee OA in Asians (allele: OR = 1.84, 95% CI 1.26–2.68; dominant: OR = 1.94, 95% CI 1.31–2.89).ConclusionsAdipokines gene polymorphisms may be associated with knee OA. The association was observed in LEPR rs1137101 in the present study. In addition, limited data revealed that associations may also exist in ADIPOQ rs2241766, VISFATIN rs4730153 and VISFATIN rs16872158.Prospero registrationCRD42020187664.
Highlights
Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting
Inclusion and exclusion criteria Two investigators assessed the retrieved studies independently according to the pre-specified inclusion criteria as follows: (1) knee OA was diagnosed based on the American College of Rheumatology criteria or radiographic findings, or the patient received total joint replacement because of primary knee OA; (2) observational studies that investigated the associations between adipokines gene polymorphisms and knee OA; (3) observational studies that compared knee OA patients with healthy controls; (4) the allele and genotype distributions of healthy controls were compliant with the Hardy–Weinberg equilibrium (HWE) model; (5) the frequency distributions of alleles and genotype were available
Meta‐analysis results The included studies covered a total of 14 single nucleotide polymorphisms (SNPs) from 5 genes, among which 5 SNPs from 3 genes were reported by at least 2 studies and were included into the metaanalysis
Summary
Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. In the past few years, several studies reported OA risk loci have been published [8,9,10,11,12], including genome-wide association studies which discovered DNA variants, primarily the single nucleotide polymorphisms (SNPs) in large cohorts [12]. Insights from these relevant studies have firmly placed OA into the polygenic category of common diseases [13,14,15,16]
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