A Single Nucleotide Polymorphism in the GDF5 Gene (rs143383) may contribute to the Increased Risk of Osteoarthritis and Lumbar Disc Degeneration: an Updated Meta-Analysis

Abstract

Background: Although previous studies have investigated the association between GDF5 polymorphism rs143383 and osteoarthritis (OA) or lumbar disc degeneration (LDD), the results were inconsistent. Given the availability of more recent data, we performed a meta-analysis to access the association between GDF5 polymorphism rs143383 and OA or LDD as well as whether the association vary by ethnicity, sex, study design and disease sites. Method: Published literature from PubMed, Embase, SCOPUS, Google Scholar, and China National Knowledge Infrastructure (CNKI) databases were retrieved. ORs and 95%CIs were calculated to estimate the strength of the association between the GDF5 polymorphism rs143383 and the risk of OA or LDD. Results: A total of 15 articles containing 33 studies were enrolled in this meta-analysis. Overall, a statistically association was found between the GDF5 rs143383 polymorphism and the risk of OA or LDD in the allele model(OR=0.86, 95%CI=0.81- 0.91) and dominant model(OR=0.86, 95%CI=0.79-0.91). In the subgroup analyses by ethnicity, sex, study design and disease site, we observed a significant association in Caucasian subgroup (allele model, OR=0.91,95%CI=0.87-0.95, dominant model, OR=0.89, 95%CI=0.82-0.96), Asian subgroup (allele model, OR=0.72, 95%CI=0.61-0.84, dominant model, OR=0.69, 95%CI=0.56-0.85), case-control study subgroup (allele model, OR=0.80, 95%CI=0.73-0.88, dominant model, OR=0.80, 95%CI=0.70-0.91), cohort study subgroup (allele model, OR=0.91, 95%CI=0.86-0.97, dominant model, OR=0.87,95%CI=0.79-0.96), males and females subgroup(allele model, OR=0.86, 95%CI=0.81-0.92, dominant model, OR=0.84, 95%CI=0.77-0.92), and weight-bearing joints subgroup(allele model, OR=0.83,95%CI=0.78-0.89, dominant model, OR=0.80, 95%CI=0.73-0.88). Conclusion: Our study demonstrated significant associations between the rs143383 polymorphism and the susceptibility to OA and LDD.