Abstract
Cholelithiasis i.e. gallstone disease (GD) is one of the common gastrointestinal disorders prevalent in about 10-15% of adults in the developing countries. Cholecystectomy, i.e. surgical removal of the gallbladder and gallstones, is the treatment of choice currently. Studies over many years ago showed that more than 50% of patients with gallstone would have lipid disorder. The disease mechanism i.e. pathogenesis of cholesterol gallstone is widely accepted as an altered lipid metabolism, because of which there is a relative increase in the cholesterol levels compared to other lipids secreted by the liver into the bile [1-3]. Association between gallstones and altered lipid profile and hypomotility of the gallbladder have been reported in some studies [4-7].
Highlights
Cholelithiasis i.e. gallstone disease (GD) is one of the common gastrointestinal disorders prevalent in about 10-15% of adults in the developing countries
About associations for Apolipoproteins A1 (ApoA1) levels between normal control subjects (NCs) and Pts, no significant correlations were noted among the groups compared (P>0.05)
The findings on associations among the parameters between NCs and Pts (I0, II0) suggested their involvements in the aetiopathogenesis of the disease. They were discussed in the light of recent knowledge for altered Lp(a) and Apolipoproteins status and molecular events in the pathogenesis of GD
Summary
Cholelithiasis i.e. gallstone disease (GD) is one of the common gastrointestinal disorders prevalent in about 10-15% of adults in the developing countries. Studies over many years ago showed that more than 50% of patients with gallstone would have lipid disorder. Association between gallstones and altered lipid profile and hypomotility of the gallbladder have been reported in some studies [4,5,6,7]. Apolipoproteins A1 (ApoA1) and ApoE and Mucin and cholesterol ester transfer protein (CETP) have been implicated with cholelithiasis in many studies [2,7,8]. High density lipoprotein-cholesterol (HDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and Lp(a) were implicated with coronary artery disease (CAD), diabetes mellitus (DM), polycystic ovarian syndrome (POS) [1,9,10,11,12]. Structural features of apolipoproteins enable them to bind to lipid end and still interact with the surrounding aqueous environment [1,2]
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