Abstract
GPR88, coding for a G protein-coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22-p21, a chromosomal region that we have previously linked to bipolar disorder (BD) in the Sardinian population. In order to ascertain the relevance of GPR88 as a risk factor for psychiatric diseases, we performed a genetic association analysis between GPR88 and BD in a sample of triads (patient and both parents) recruited in the Sardinian and the Palestinian population as well as between GPR88 and schizophrenia (SZ) in triads from the Xhosa population in South Africa. We found a positive association between GPR88 and BD in the Sardinian and Palestinian triads. Moreover, we found a positive association between GPR88 and SZ in triads from the Xhosa population in South Africa. When these results were corrected for multiple testing, the association between GPR88 and BD was maintained in the Palestinian population. Thus, these results suggest that GPR88 deserves consideration as a candidate gene for psychiatric diseases and requires to be further investigated in other populations.
Highlights
A genome-wide scan on a sample of 88 nuclear families with at least two affected sibs with bipolar disorder (BD) recruited in the Sardinian population, showed positive nonparametric linkage (NPL) scores exceeding 3.4 with P-values
The GPR88 gene is located in the region previously found to be linked to BD in the Sardinian population (Del Zompo et al 2010)
It is less than 4000 kb on the telomeric side of D1S293, which with D1S424 and D1S2804 constitutes a block of markers displaying NPL scores exceeding 2.35
Summary
A genome-wide scan on a sample of 88 nuclear families with at least two affected sibs with bipolar disorder (BD) recruited in the Sardinian population, showed positive nonparametric linkage (NPL) scores exceeding 3.4 with P-values
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