Abstract
The effects of bisphenol A (BPA) on asthma have been reported in various in vitro, animal, and human epidemiologic studies. However, epidemiological studies on the effects of bisphenol S (BPS) and bisphenol F (BPF), which are substitutes of BPA, on asthma are lacking. The purpose of this study was to identify the association between BPA, BPS, and BPF and asthma. An asthma-related questionnaire; urinary BPA, BPS, BPF; and the possible confounders were analyzed among 922 adolescents aged 12–17 years who participated in the Korean National Environmental Health Survey 2016. In males, urinary BPA, BPS, and BPF did not show a significant relationship with the lifetime prevalence of asthma. In females, urinary BPS was higher in the asthma group (p < 0.01). High urinary BPS showed a significant relationship with a high odds ratio (OR) of lifetime asthma prevalence in the model adjusted for possible confounders (p < 0.05). High urinary BPS was particularly associated with an increase in the OR of asthma diagnosed after the age of 60 months (p < 0.01). Urinary BPS was significantly associated with asthma diagnosis, especially after the age of 60 months, among Korean adolescent females.
Highlights
Bisphenols are widely used in plastic products, receipt ink, and medical equipment production [1,2]
There were no significant differences in general characteristics and urinary bisphenols according to asthma diagnosis
It is not possible to identify the causal relationship between bisphenol S (BPS) and asthma in this cross-sectional study, considering the pathophysiological evidence revealed by previous animal and in vitro studies, this study suggests the possibility that BPS will affect the onset of asthma
Summary
Bisphenols are widely used in plastic products, receipt ink, and medical equipment production [1,2]. The toxicity of bisphenol A (BPA) (4,40 -(propane-2,2-diyl) diphenol) is widely known [5], and there are restrictions on its use in industry, consumer products including epoxy resin-based paints, and thermal paper [6]. As a result, it has been replaced with other bisphenol analogues, such as bisphenol F (BPF) (4,4-dihydroxydiphenyl-methane) or bisphenol S (BPS) (4,40 -sulfonylbisphenol). The toxicity of bisphenol A analogues is expected to be similar to that of BPA as a result of similar chemical properties and has been reported in several studies [7,8]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call