Abstract
Pregnancy is related to change in glucose metabolism and insulin production. The aim of our study was to determine the association of serum IFN-γ and TGF-β levels with insulin resistance during normal pregnancy. This cross sectional study was carried out on 97 healthy pregnant (in different trimesters) and 28 healthy non-pregnant women. Serum TGF-β and IFN-γ level were measured by ELISA method. Pregnant women had high level TGF-β and low level IFN-γ as compared non-pregnant women. Maternal serum TGF-β concentration significantly increased in third trimester as compared first and second trimester of pregnancy. Maternal serum IFN-γ concentration significantly decreased in third trimester as compared first and second trimester of pregnancy. Pregnant women exhibited higher score of HOMA IR as compared non-pregnant women. There were association between gestational age with body mass index (r=0.28, P=0.005), TGF-β (r=0.45, P<0.001) and IFN-γ (r=-0.50, P<0.001). There was significant association between Insulin resistance and TGF-β (r=0.17, p=0.05). Our findings suggest that changes in maternal cytokine level in healthy pregnant women were anti-inflammatory. Furthermore, Tumor Growth Factor-β appears has a role in induction insulin resistance in healthy pregnant women. However, further studies needed to evaluate role of different cytokines on insulin resistance in normal pregnancy.
Highlights
Pregnancy is related to change in glucose metabolism and insulin production, regulation and action
Our data confirm previous results that insulin resistance was increased in pregnant patients (Kirwan et al, 2002)
TGF-β isoforms involved in the control of apoptosis in the uterus during pregnancy (Shooner et al, 2005) and apoptosis plays an important role during embryo implantation and during late pregnancy, especially during regression of the decidua basalis (Welsh, 1993; Pampfer & Donnay, 1999)
Summary
Pregnancy is related to change in glucose metabolism and insulin production, regulation and action. There are reports that show longitudinal changes in insulin resistance in healthy and diabetic subjects have been correlated with cytokines and adipokine concentration (Bruun, Stallknecht, Helge, & Richelsen, 2007; Fève & Bastard, 2009). In addition previous studies have been shown, there is correlation between insulin resistance with maternal level of a number of cytokines in normal and complicated pregnancies (Zhang et al, 2006). IFN-γ is a cytokine that secrets by Th1cells.It has role in the regulation of almost all phases of immune and inflammatory responses. This cytokine was identified in all gestational tissues (Veith & Rice, 1999).
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