Abstract
Several single nucleotide polymorphisms have been identified in cyclooxygenase-2 (COX-2) genes (e.g., −765 G>C (rs20417), −1195G>A (rs689466), and 8473 C>T (rs5275)). The association of these SNPs with the risk of different cancer types is still controversial. This study aims to evaluate the correlation between these SNPs and breast cancer risk in different ethnic groups. We have searched PubMed, Web of Knowledge, and Embase for relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the associations. A total of 13 studies (15,330 cases and 19,260 controls) were eligible for meta-analysis. This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. The rs5275 polymorphism had no association with breast cancer risk.
Highlights
Breast cancer is the most common cancer in women worldwide [1]
We searched the electronic databases of PubMed, Web of Knowledge, and Embase to collect articles with case-control studies related to the association of COX-2 polymorphisms with breast cancer risk
There were six studies with 9,938 cases and 12,618 controls included to evaluate the relationship between rs20417 polymorphism and breast cancer risk
Summary
Breast cancer is the most common cancer in women worldwide [1] It is a multifactorial disease caused by complex genetic and environmental factors [2]. Previous researches have suggested that the risk of breast cancer is affected by multiple environmental factors as well as genetic alterations, such as genetic polymorphisms [3, 4]. COX-2 can be rapidly induced by a variety of mitogenic and inflammatory stimuli and elevate the production of prostaglandins, which contribute to tumor occurrence and progression by modulating cell proliferation, apoptosis, and angiogenesis [6,7,8]. Targeted inhibition of COX-2 blocked the proliferation of breast cancer cell lines in vitro and prevented the occurrence of rat breast cancer chemically induced by DMBA [12]
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