Association between three functional microRNA polymorphisms (miR-499 rs3746444, miR-196a rs11614913 and miR-146a rs2910164) and breast cancer risk: a meta-analysis.

Hong Zhang,Xixi Zhao,Xiaoyan Gao,Wanjun Yan,Xingcong Ma,Shuqun Zhang,Yafei Zhang,Wen Wang

doi:10.18632/oncotarget.13426

Abstract

Three functional microRNA polymorphisms (miR-499 rs3746444 A > G, miR-196a rs11614913 C > T and miR-146a rs2910164 G > C) have been reported to be associated with breast cancer (BC) risk. However, the results of the published studies are inconsistent. In order to obtain a more credible result, we conducted this meta-analysis. We searched PubMed, EMBASE and Web of Science databases to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association. Thirty-eight eligible studies with 17,417 cases and 18,988 controls were included in this meta-analysis. Our results showed that the rs3746444 was associated with an increased breast cancer risk in the four genetic models (G vs. A: OR = 1.17, P = 0.008; GG vs. AA: OR = 1.41, P < 0.001; AG vs. AA: OR = 1.10, P = 0.036; GG+AG vs. AA: OR = 1.16, P = 0.001). In the subgroup analysis by ethnicity, significant correlation remained in Asians but not in Caucasians. For rs11614913, obvious decreased breast cancer risk was observed in Caucasian populations (T vs. C: OR = 0.93, P = 0.044). However, we couldn't detect an association between rs2910164 and breast cancer risk. This meta-analysis demonstrates that rs3746444 could increase breast cancer risk in Asians and in general populations, while rs11614913 could decrease the risk of breast cancer in Caucasians. The rs2910164 polymorphism has no association with breast cancer risk. More multicenter studies with larger sample sizes are required to verify our results.

Highlights

Breast cancer is the most common malignancy tumor among women, which accounts for 25% of all cancer cases in women all over the world, and it is the principal cause of female cancer-related death [1]
Our results showed that the rs3746444 was associated with an increased breast cancer risk in the four genetic models (G vs. A: odds ratios (ORs) = 1.17, P = 0.008; GG vs. AA: OR = 1.41, P < 0.001; AG vs. AA: OR = 1.10, P = 0.036; GG+AG vs. AA: OR = 1.16, P = 0.001)
This meta-analysis demonstrates that rs3746444 could increase breast cancer risk in Asians and in general populations, while rs11614913 could decrease the risk of breast cancer in Caucasians

Summary

Introduction

Breast cancer is the most common malignancy tumor among women, which accounts for 25% of all cancer cases in women all over the world, and it is the principal cause of female cancer-related death [1]. The occurrence and development of breast cancer is a multistep, multistage complicated process involving multiple factors, among which genetic factors are considered to play a crucial role [3]. MiRNAs are highly conserved, tissue-specific and taking part in the regulation of many physiological and pathological process, such as cell differentiation, cell proliferation, cell apoptosis, fat metabolism, etc [5, 6]. MiRNAs have many important functions: among them, the function of microRNAs in cancer occurrence and progression attracts the most attention [7]

Methods

Results

Conclusion