Abstract
In previous studies, it has been documented that a short reproductive period is associated with a higher risk of diabetes, cardiovascular disease, and chronic kidney disease. This study aims to investigate the association of the reproductive period length with decreased renal function. This study obtained data from “the Shanghai Suburban Adult Cohort and Biobank”. An estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m2 indicated decreased renal function during follow-up. Participants were grouped into quintiles by reproductive period. Logistic regression analysis was performed to examine the association between the reproductive period and decreased renal function. A total of 5503 menopausal women with baseline eGFR > 60 mL/min/1.73 m2 were included. Age, eGFR, and metabolic equivalent of task (MET) at baseline were 61.0 (range, 36.0–74.0) years, 92.2 (range, 60.1–194.5) mL/min/1.73 m2, and 1386 (range, 160–6678), respectively. A reproductive period of 37–45 years was associated with a lower risk of decreased eGFR (OR: 0.59, 95% CI: 0.35–1.00, p = 0.049) after adjusting for confounding variables. METs decreased the risk of decreased eGFR in women with a reproductive period of 37–45 years (OR: 0.43, 95% CI: 0.23–0.81, p = 0.010). Women with a longer reproductive period have a lower risk of decreased renal function. METs had an opposite influence on renal function in women with longer (decreased risk) or shorter (increased risk) reproductive periods.
Highlights
IntroductionChronic kidney disease (CKD) is a progressive and lifelong disease causing a severe public health problem [1]
This study was based on the data obtained from the “Shanghai Suburban Adult Cohort and Biobank (SSACB)”, which is a community-based cohort study conducted by the School of Public Health of Fudan University in collaboration with the Shanghai Songjiang Center for Disease Prevention and Control from June 2016 to August 2020 [32]
A total of 5503 menopausal women were included in this prospective cohort
Summary
Chronic kidney disease (CKD) is a progressive and lifelong disease causing a severe public health problem [1]. CKD is characterized by abnormalities of kidney structure or function that are present for >3 months, including a glomerular filtration rate (GFR). There were 752.7 million CKD patients worldwide in 2016, of which 55% were women [2]. CKD complications can include cardiovascular disease (CVD), hypertension, anemia, bone disease, electrolyte abnormalities, and, in the end stages, uremia [1,3]. CKD is a risk factor for mortality [4,5,6].
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