Abstract
Abstract Osteoporosis is a condition characterized by low bone mineral density (BMD) and micro-architectural changes in the bone tissue. The risk of osteoporosis is partly determined by genetic factors. The role of C677T polymorphism of methylenetetrahydrofolate reductase ( MTHFR) gene has been investigated in postmenopausal osteoporosis. However, the relationship between MTHFR polymorphism and BMD is still controversial. We carried out a meta-analysis of 5,833 subjects to evaluate the association of MTHFR and BMD in postmenopausal women. Databases of MEDLINE, Web of Science, Scopus and CNKI were retrieved for all publications relating to MTHFR polymorphism and BMD in postmenopausal women. Five eligible studies were selected for meta-analysis. All these articles studied the association of MTHFR polymorphism and BMD of the femoral neck and lumbar spine in postmenopausal women. Our analysis suggested that postmenopausal women with the TT genotype had lower femoral neck BMD than the women with the CC/CT genotype, and the weighted mean difference (WMD) was −0.01 g/cm 2 [95% confidence interval (CI): (−0.01, −0.01), P < 0.01]. However, BMD of the lumbar spine of postmenopausal women with the TT genotype was not significantly different from that of women with the CC/CT genotype. In the random effects model, the WMD between the TT and TC/CC genotype was −0.01 g/cm 2 [95% CI: (−0.04, 0.01), P = 0.32]. The C677T polymorphism of the MTHFR gene is associated with BMD of the femoral neck in postmenopausal women. Women with the TT genotype of the MTHFR gene have lower BMD, suggesting that the TT genotype may be a risk factor for postmenopausal osteoporosis.
Highlights
Osteoporosis is a common metabolic bone disorder characterized by reduced bone mass, increased skeletal fragility and micro-architectural deterioration, and, as a consequence, increased bone fracture[1]
Articles published in all languages were selected if they met all of the following criteria: (1) study included postmenopausal women with femoral neck and/or lumbar spine bone mineral density (BMD); (2) study stratified by methylenetetrahydrofolate reductase (MTHFR) C677T genotypic class in TT and CC/CT genotype or in TT, CC and CT genotype; (3) the BMD of each participant was measured by dual-energy X-ray absorptiometry; (4) those that retrieved studies of review articles were excluded
The five studies[21,22,23,24,25] on the association between the MTHFR C677T polymorphism and BMD of the femoral neck in postmenopausal women involved 542 subjects with the TT genotype and 4,855 subjects with the CC/CT genotype, and the lumbar spine BMD data included 607 subjects with the TT genotype and 5,226 subjects with the CC/CT genotype, and detailed characteristics of each study are described in Table 1 and Table 2
Summary
Osteoporosis is a common metabolic bone disorder characterized by reduced bone mass, increased skeletal fragility and micro-architectural deterioration, and, as a consequence, increased bone fracture[1].
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