Association of Symptoms of Gastroesophageal Reflux with Metabolic Syndrome Parameters in Patients with Endocrine Disease

Masatoshi Nomura,Akie Hirata,Naotaka Tashiro,Ryoichi Takayanagi,Taijiro Okabe,Ichiro Abe,Tetsuhiro Watanabe

doi:10.1155/2014/863206

Abstract

Background. Metabolic syndrome (MetS) and obesity are known risk factors for gastroesophageal reflux disease (GERD), which is often found in patients with endocrine disorders, such as thyroid dysfunction and hypopituitarism. To clarify the relationship of endocrine disease with GERD, we investigated the symptoms of GERD in patients with various endocrine diseases. Methods. Patients with various endocrine disorders who visited Kyushu University Hospital were included. GERD symptoms were examined using a self-administered questionnaire, the frequency scale for the symptoms of GERD (FSSG). Metabolic parameters, including body-mass index (BMI), waist circumference, blood pressure, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides, and values of endocrine function, including thyroid stimulating hormone, free thyroxin, cortisol, and insulin-like growth factor-1, were assessed. Results. A total of 111 consecutive patients were recruited for the study. Among these, 18 (16.2%) patients were considered to have GERD. Among the parameters, BMI (P = 0.03) and triglycerides (P = 0.001) showed a positive association and HDL-C (P = 0.0007) showed an inverse association with the FSSG score. However, none of the endocrine values were associated with the FSSG score. Conclusion. Symptoms of GERD in patients with endocrine disorders might be attributed to MetS as comorbidity.

Highlights

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities defined as the presence of three or more of the following factors: abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol (HDL-C) levels, high blood pressure, and high fasting plasma glucose levels [1]
We investigated the association between the FSSG score and endocrine values, as well as MetS parameters in patients with various endocrine disorders
We found that body-mass index (BMI), triglyceride, and HDL-C levels were associated with

Summary

Background

Metabolic syndrome (MetS) and obesity are known risk factors for gastroesophageal reflux disease (GERD), which is often found in patients with endocrine disorders, such as thyroid dysfunction and hypopituitarism. Patients with various endocrine disorders who visited Kyushu University Hospital were included. Metabolic parameters, including body-mass index (BMI), waist circumference, blood pressure, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides, and values of endocrine function, including thyroid stimulating hormone, free thyroxin, cortisol, and insulin-like growth factor-1, were assessed. BMI (P = 0.03) and triglycerides (P = 0.001) showed a positive association and HDL-C (P = 0.0007) showed an inverse association with the FSSG score. None of the endocrine values were associated with the FSSG score. Symptoms of GERD in patients with endocrine disorders might be attributed to MetS as comorbidity

Introduction

Methods

Results

Discussion

F RS Standardized β