Abstract
Background and Aims : As a member of sirtuin family of class III histone deacetylase enzymes, SIRT6 has been involved in all key pathways that are (dis)regulated during atherogenesis. Its multiple effects mostly exert by deacetylating histone 3 at the promoter region of its target genes including those regulating DNA damage, telomere maintenance, aging, inflammation, cell proliferation, apoptosis, glucose, and lipid metabolism. Recent study has shown that overexpression of SIRT6 in mice model of unstable carotid plaque, promotes angiogenesis and intraplaque hemorrhage.
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