Abstract
9018 Background: Host genetics has so far not been appreciated as an important factor in adjuvant and palliative study design in melanoma. Single nucleotide polymorphisms (SNPs) in DNA repair genes may affect not only cancer predisposition, but also progression and survival of primary cutaneous melanoma patients. We evaluated the association of SNPs in DNA repair genes with overall survival (OS), metastasis-free survival (MFS) and survival following the first metastasis (SFM) in patients with primarily unmetastasized melanoma. Methods: 13 SNPs in 8 DNA repair genes were evaluated in 400 primary melanoma patients (any T,N0,M0) using genotyping assays and associated with follow-up data of these patients. Deviation of Hardy-Weinberg equilibrium using the Pearson-x2 test, censored survivorship function Kaplan-Meier, log-rank test were used. Cox Hazards regression modeling and multivariate analysis models including age, gender and Breslow were employed. Results: Of the evaluated SNPs 4 showed significant assoc...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
