Abstract
9018 Background: Host genetics has so far not been appreciated as an important factor in adjuvant and palliative study design in melanoma. Single nucleotide polymorphisms (SNPs) in DNA repair genes may affect not only cancer predisposition, but also progression and survival of primary cutaneous melanoma patients. We evaluated the association of SNPs in DNA repair genes with overall survival (OS), metastasis-free survival (MFS) and survival following the first metastasis (SFM) in patients with primarily unmetastasized melanoma. Methods: 13 SNPs in 8 DNA repair genes were evaluated in 400 primary melanoma patients (any T,N0,M0) using genotyping assays and associated with follow-up data of these patients. Deviation of Hardy-Weinberg equilibrium using the Pearson-x2 test, censored survivorship function Kaplan-Meier, log-rank test were used. Cox Hazards regression modeling and multivariate analysis models including age, gender and Breslow were employed. Results: Of the evaluated SNPs 4 showed significant assoc...
Published Version
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