Abstract
Irisin, a recently identified novel myokine, drives brown-fat-like conversion of white adipose tissues and has been proposed to mediate beneficial effects of exercise on metabolism. Circulating irisin was significantly reduced in type 2 diabetes patients; however, no evidence is available about its association with metabolic syndrome (MetS) and effects of adiposity and muscle mass on circulating irisin have been controversial. Cross-sectional data on socio-demographic, lifestyle, clinical characteristics and serum irisin were collected for 1,115 community-living Chinese adults with central obesity. Associations of serum irisin with MetS (central obesity plus any two of the following four factors (raised blood pressure (BP), raised fasting plasma glucose (FPG), raised triglyceride (TG), and reduced HDL cholesterol) and each component of MetS were analyzed using multivariable logistic regression. Among the 1,115 obese Chinese adults with a mean age of 53.2(±7.2) years, serum irisin levels (log-transformed) were significantly reduced in subjects with MetS and raised FPG than their control groups (p = 0.034 and 0.041, respectively). After adjustment for potential confounders, serum irisin was significantly associated with reduced risks of MetS and raised FPG, with odds ratios (ORs) (95% CI) per standard deviation of log-transformed irisin of 0.796 (0.505–0.959, p = 0.027) and 0.873 (0.764–0.998, p = 0.046), respectively. Associations of irisin with raised BP, raised TG and reduced HDL were not statistically significant ((ORs) (95% CI): 0.733(0.454–1.182, p = 0.202), 0.954(0.838–1.086, p = 0.478) and 1.130(0.980–1.302, p = 0.092), respectively). Stepwise multivariable linear regression analysis showed that fasting insulin, HbA1c and albumin/globulin ratio were negatively associated with serum irisin level with statistical significance (all p-values <0.05) and waist circumference was negatively associated with serum risin with marginally statistical significance (p = 0.055). These results imply that irisin may play an important role in insulin resistance and MetS and should be confirmed in future prospective studies.
Highlights
Metabolic syndrome (MetS) represents a cluster of atherogenic risk factors including hypertension, insulin resistance, obesity and dyslipidemia, and is considered as a major public health problem because of its rapidly increasing prevalence worldwide and its association with type 2 diabetes and cardiovascular disease [1,2,3]
We found that increasing serum irisin was significantly associated with reduced risks of MetS and raised Fasting plasma glucose concentration (FPG) even after adjustment for potential confounding factors, while the associations of serum irisin with rasied blood pressure and raised triglyceride were not statistically significant
We found that fasting insulin, HbA1c and serum A/G ratio were negatively associated with serum irisin after adjusting for covariates
Summary
Metabolic syndrome (MetS) represents a cluster of atherogenic risk factors including hypertension, insulin resistance, obesity and dyslipidemia, and is considered as a major public health problem because of its rapidly increasing prevalence worldwide and its association with type 2 diabetes and cardiovascular disease [1,2,3]. As a lifestyle intervention approach, has been consistently shown to be effective in reducing incidence of type 2 diabetes [4,5] and MetS [6], which made the discovery that physical exercise provokes increases in a number of cytokines from skeletal muscle as a potential mechanism sound plausible. No evidence is available on whether circulating irisin is involved in metabolic syndrome in adults
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
