Association of Serum Adiponectin with Dysglycemia and Dyslipidemia in Impaired Glucose Tolerance and Type 2 Diabetes Mellitus

Abstract

Background: The association of low adiponectin concentration and type 2 diabetes is well studied but the association of adiponectin with prediabetes is still unresolved. Data from Bangladeshi population shows that both insulin secretory defect and insulin resistance are present in T2DM subjects, but the secretory defects seem to have a predominant role. In a search for the downward factors regulating the basic defects attention has also been focused to inflammatory markers and adipocytokines. Adiponectin is one of the major targets for such studies and few studies have already been conducted on the association of adiponectin with prediabetes in our population. Objective: The objective of our study was to evaluate adiponectin level in subjects with pre-diabetes and to compare it with the levels in newly diagnosed type 2 diabetes and healthy (normal glucose tolerance) subjects. Method: It was an observational analytic study with a group compare design. The study was conducted in the Biomedical Research Group and Department of Biochemistry & Cell Biology of the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka. This study was done during the period of July 2012 to June 2013. Results: IGT and Controls subjects were age and BMI matched. Mean (±SD) age of Control, IGT and T2DM subjects were 38.75±8.40, 42.71±7.65 and 44.61±7.00 years respectively. Age of T2DM subjects were higher compared to controls (p=0.022). Mean (SD) BMI of the Control, IGT and T2DM subjects were 20.53±2.43, 20.89±2.22 and 21.14±2.23 respectively. Conclusion: From our study we can conclude that, type 2 DM subjects have lower adiponectin level compared to controls. Prediabetic subjects do not have lower adiponectin level, but they have a lower adiponectin- glucose ratio compared to controls.