Abstract
Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.
 
 Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.
 
 Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.
 
 Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.
Highlights
Introduction and AimThe atherosclerosis is the major cause of morbidity and mortality among diabetes population
We found significant increase (p value
Serum Adenosine deaminase (ADA) used as a biomarker for evaluation of glycemic status
Summary
Introduction and AimThe atherosclerosis is the major cause of morbidity and mortality among diabetes population. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index. Diabetes is a disorders characterized by variable degrees of insulin resistance, impaired insulin secretion and increased glucose production [1]. Prevalence of Type 2 Diabetes Mellitus (T2DM) is a global public health threat [2,3,4]. The metabolic disturbance causes secondary pathophysiologic changes in multiple organ systems. This imposes a tremendous burden on the individual as well as health care system of both developed and developing countries.
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