Association of rs3025058 polymorphism with the development of acute cerebrovascular event

Abstract

Abstract Purpose To study SNP rs3025058 association (5a/6a) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results In all analyzed groups and subgroups of patients statistically significant connection between a genotype of 5a/5a and an allele of 5a and in subgroup of women with Acute Cerebrovascular Event, subgroups of patients with AG and hypercoagulation of significant associations of polymorphism rs3025058 (5a/6a) with Acute Cerebrovascular Eventis not revealed. Conclusion A genotype 5a/5a and an allele 5a SNP rs3025058 (5a/6a) increase risk of development of an Acute Cerebrovascular Event in persons of the east Siberian population, including with such risk factors as atherosclerosis the brachiocephalic of arteries and a dislipidemiya. Funding Acknowledgement Type of funding sources: None.