Association of rs12122341 polymorphism with the development of acute cerebrovascular event

Abstract

Abstract Purpose To study SNP rs12122341 (C> G) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results As a result of a research gender differences in functions of genotypes of SNP rs12122341 are set (C> G). So, for males risk factor of Acute Cerebrovascular Event is the genotype of CC, for female persons – CG genotype. In the general group of patients with Acute Cerebrovascular Event and also in subgroups of patients with different cardiovascular pathology and risk factors of statistically significant differences in frequencies of genotypes and alleles it is not revealed. Conclusion A genotype of the CC SNP rs12122341 (C> G) the risk of development of Acute Cerebrovascular Event in males in comparison with genotypes of CG and GG (p=0.009 raises; OR 1.83, 95% of CI: 1.16–2.91). The genotype of CG performs protective function concerning development of Acute Cerebrovascular Event in males. At female persons risk factor of development of Acute Cerebrovascular Event is CG genotype. Funding Acknowledgement Type of funding sources: None.