Association of Retinol Binding Protein-4 and Microalbuminuria and Blood Glucose Regulation in Type 2 Diabetic Iraqi Patients

Abstract

Retinol binding protein 4 (RBP-4) has long been known as the carriers for vitamin A, in the plasma it is banded to transthyretin to form too large complex for glomerulus filtration. Discovered as adipokine involved in the pathogenesis of type 2 diabetes induced insulin resistant and linked to obesity. Diabetic nephropathy one of serious microvascular complication that impact large numbers of the patient however, association with RBP-4 is not fully known. The present study tested this hypothesis by measuring serum RBP4 in samples of Iraqi type 2 diabetic (n=120) with normal albumin excretion (n=57) and microalbuminuria (n=63) of either sex. and Also apparently health subjects (n=30) were involved to serve as control. Concentrations of the RBP4 were significantly elevated in serum of microalbuminuric diabetic patients as compare with normoalbuminuric patients, (p=0.000<0.05). also glycemic index parameters significantly higher (for all p<0.05). In conclusion, the study suggested that serum level of RBP4 are affected by microalbuminuria and the assessment of RBP-4 as controller for insulin resistant in type 2 diabetic in further studies must take into consideration other renal problems.