Abstract

ObjectiveNasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. Genetic susceptibility is a major contributing factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in regenerating gene 1A (REG1A), we conducted a hospital-based case–control study in a Cantonese-speaking population from Guangdong province.MethodsWe endeavored to determine whether genetic variants of the REG1A gene were associated with the risk of NPC amidst the Cantonese population in a hospital-based case–control study using polymerase chain reaction-restriction and direct sequencing analysis in 211 NPC patients and 150 healthy controls. The association between NPC risk and the 14C/T, 20C/T, 369G/T, 1201A/G, and 2922C/T polymorphisms was examined after adjustment for age and sex.ResultsWe found an increased risk of developing NPC in individuals with REG1A 2922C/T variant genotype (p = 0.003, OR 0.419, 95% CI 0.235–0.746), and after adjustment for sex and age (p = 0.003, OR 0.406, 95% CI 0.226–0.732). No association between other polymorphisms (14C/T, 20C/T, 369G/T, and 1201A/G) and the risk of NPC was observed, before or after adjustment for age and sex.ConclusionOur findings suggest that the REG1A 2922C/T polymorphism is associated with an increased risk of developing NPC in a Cantonese population from Guangdong province. Larger studies are required to confirm our findings and unravel the underlying mechanisms.

Highlights

  • Nasopharyngeal carcinoma (NPC) originates from the epithelial lining of the nasopharynx [1]

  • We found that the regenerating gene 1A (REG1A) 2922C/T variants are associated with an increased risk of NPC and may be a novel biomarker for the screening and early diagnosis of NPC

  • The distribution of each REG1A gene polymorphism in total samples conformed to the Hardy–Weinberg equilibrium (p = 1 for REG1A-14, p = 1 for rs117580393, p = 1 for rs768985544 and p = 0.06995 for rs12072; supplementary table 1), except for re10165462 (p = 0.002; supplementary Table 1)

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Summary

Introduction

Nasopharyngeal carcinoma (NPC) originates from the epithelial lining of the nasopharynx [1]. It is characterized by a higher incidence in Southern China and Southeast Asia, at 20–30 per 100,000 people [2]. The etiology of NPC is not clear, but genetic susceptibility, Epstein–Barr virus (EBV) infection and environmental factors are predisposing factors. Extended author information available on the last page of the article for NPC [3, 4]. Different individuals exposed to the same environmental factors will have distinct presentation, suggesting that genetic variation is the key risk factor for the development of NPC [5]

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