Association of Polymorphism in IL-18 Gene with Periodontitis in Uyghur Adults in Xinjiang and Evidence from Six Case‐Control Studies with a Comprehensive Analysis

Abstract

ABSTRACT Aim The aim of the study was to evaluate the association of IL‐18 137 G > C, 607 C > A gene polymorphism in Uyghur population with chronic periodontitis (CP) and combine the results with the meta-analysis Methods In a case‐control study, 200 cases with CP and 100 healthy controls were recruited; IL‐18 137 G > C, 607 C > A genotyping was performed by polymerase chain reaction‐restriction fragment length polymorphism (PCR-RFLP). In the meta‐analysis, we used electronic databases, including CNKI, Wan Fang, PubMed, EMBASE databases etc.to obtain relevant research published through June 2020. Studies were considered eligible if odds ratios (ORs) and 95% confidence intervals (95% CI) were provided or calculated from the given data. The size of the combined effect was calculated using STATA 15.0 Results Our study revealed significant association between CP and IL‐18 137 G > C (P = .045, OR = 1.67), 607 C > A (P = .045, OR = 1.67). The overall meta‐analysis revealed significant associations between IL‐18 137 G > C polymorphism and CP risk in Allele, dominant, co-dominant and recessive genetic models. The subgroup analysis also showed a significant association between the IL‐18 137 G > C and risk for periodontitis and aggressive periodontitis in the Asian (GC+ CC VS. GG: P = .047, OR = 1.64,95%CI = 1.01–2.68) Conclusions IL‐18 137 G > C, 607 C > A could be associated with susceptibility to periodontitis in Uyghur population. Further case-control of candidate genes studies targeting larger sample sizes and different ethnic groups are needed to arrive more accurate conclusions.