Association of Polycystic Ovarian Syndrome with Metabolic Disorders

Abstract

Objective: To determine the association of Metabolic Disorders in women of reproductive age with polycystic ovarian syndrome (PCOS) Study Design and setting: Cross Sectional Study conducted in the Department of Gynecology and Obstetrics, Ward 9, Jinnah Postgraduate Medical Center, Karachi. Methodology: The study was conducted from November 2021 to February 2022. A total of 227 diagnosed patients of PCOS were included in this study. Five components of Metabolic syndrome were assessed: Body Mass Index (BMI), blood pressure, central obesity, fasting blood sugar and lipid profile. Informed consent was obtained from all participants. Patients’ history, physical examination and laboratory investigations in terms of symptoms and findings relating to MS were recorded and assessed using SPSS version 21. Descriptive statistics were calculated and stratification was done. Chi-square test used post stratification and p-value =0.05 were considered significant. Results: Mean age was 27.05±4.51 years. Mean symptom duration was 11.26±3.02 months. Central obesity, hypertension, hypertriglyceridemia, HDL-cholesterol <50 mg/dl and fasting glucose >100 mg/dl were found in 44.9%, 31.7%, 38.3%, 27.3%, and 38.8% patients, respectively. A total of 47 (20.7%) study subjects were identified with two or more above components of MS. Significant association of MS with age (>27 years; p<0.000) and duration of disease (>12 months; p<0.000) was observed. Conclusion: A higher prevalence of MS was observed when participants aged more than 27 years and had symptoms for more than a year. Higher BMI was also found nearing statistical significance