Abstract
Aim: To date, findings on the overall and sex-specific effects of plasma pyridoxal 5′-phosphate (PLP, active coenzyme form of vitamin B6) on the risk of coronary heart disease (CHD) have been inconsistent. This study sought to advance our understanding on the association of plasma PLP with risk of CHD, with particular attention paid to sex differences and effect modifiers.Methods: We conducted a hospital-based, case-control study on suspected CHD patients undergoing diagnostic coronary angiography. A total of 429 CHD cases and 429 controls matched by age, sex, and operation time were included in the final analysis. Plasma PLP was assessed using LC-MS. Logistic regression analyses were performed to evaluate the association between plasma PLP and a first CHD event.Results: The mean (SD) plasma PLP levels were 8.4 (6.3) in male cases and 9.0 (11.0) in female cases, and 9.5 (8.5) in male controls and 12.5 (12.9) in female controls. Each 1 ng/mL increment in log2PLP was associated with a 28% lower risk of CHD in overall population. When stratified by sex, plasma PLP was significantly and independently associated with CHD in women (OR = 0.63, 95% CI: 0.50–0.80), but not in men (OR = 0.86, 95% CI: 0.67–1.09). The association of plasma PLP with CHD risk was modified by sex (adjusted Pinteraction = 0.022).Conclusions: We found a significant, inverse linear association between plasma PLP and CHD in Chinese women, but not in men. Our findings warrant additional investigation.
Highlights
Cardiovascular diseases (CVDs) are the leading cause of global disease burden and a major contributor to disability [1, 2]
Plasma pyridoxal 5’-phosphate (PLP) was significantly and independently associated with coronary heart disease (CHD) in women (OR = 0.63, 95% confidence intervals (CIs): 0.50–0.80), but not in men (OR = 0.86, 95% CI: 0.67–1.09)
The association of plasma PLP with CHD risk was modified by sex
Summary
Cardiovascular diseases (CVDs) are the leading cause of global disease burden and a major contributor to disability [1, 2]. Among CVDs, 49% were attributable to coronary heart disease (CHD) [1]. Epidemiological investigations show that the age for developing CHD is becoming younger [3]. CHD is a major cause of both death and disability in developed countries and is responsible for one-third or more of all deaths in individuals over the age of 35 [4]. Identification and treatment of individuals at risk for CHD are essential for decreasing cardiovascular morbidity and mortality [4]. Despite significant efforts to reduce well-known traditional risk factors (e.g., hypertension, diabetes, dyslipidemia, abdominal obesity, and smoking), many countries, including China, continue to observe rising CHD incidence and mortality. The potential role of dietary factors has gained considerable attention, vitamin B6 deficiency [6,7,8]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call