Abstract
Background: Purinergic receptors can be divided into adenosine (P1) and adenosine 5’-triphosphate (ATP) (P2) receptors, which play crucial roles in regulating vessel tone, arthrosclerosis, myocardial preconditioning and heart function. However, the relationship of plasma nucleotides with coronary artery disease (CAD) and heart function have not been reported. Methods and results: Total 97 patients undergoing coronary angiogram had been tested for the plasma nucleotides, including ATP, uridine 5’-triphosphate (UTP) and adenosine monophosphate (AMP), and their association with CAD and heart function. They were divided into ST-elevation myocardial infarction (STEMI, n=33) group, unstable angina (UA, n=33) group and control (normal angiography, n=31) group. The UTP (1263.23 ± 137.76 vs. 635.61 ± 124.82 nmol/L, P Conclusion: Plasma nucleotides levels have significant association with the myocardial damage, severity of coronary arterial lesion and left ventricular systolic function in acute myocardial infarction. Key words: Coronary artery disease, Left ventricular systolic function, Purinergic receptor, ST-elevation myocardial infarction, Unstable angina.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
