Abstract
BackgroundAcute kidney injury (AKI) is a common postoperative complication of orthotopic liver transplantation (OLT). So far, little attention has been paid on the association between overweight and AKI after OLT, and animal models or clinical studies have drawn conflicting conclusions. The objective of our study was to determine whether overweight (BMI [Body Mass Index] ≥ 25 kg/m2) is associated with an increased risk of AKI after OLT.MethodsThis retrospective cohort study included 244 patients receiving OLT in the Affiliated Hospital of Qingdao University between January 1, 2017, and August 29, 2019. Preoperative, intraoperative, and postoperative data were collected retrospectively. The primary outcome was the development of AKI as defined by Kidney Disease, Improving Global Outcome (KIDGO) staging system. Logistic regression analysis was used to determine the relationship between overweight and the occurrence of postoperative AKI. Data analysis was conducted from September to October 2019, revision in April 2020.ResultsAmong 244 patients receiving OLT (mean [standard deviation] age, 54.1 [9.6] years; 84.0% male) identified, 163 patients (66.8%) developed postoperative AKI. Overweight (BMI ≥ 25 kg/m2) was associated with a higher rate of postoperative severe AKI (stage 2/3) compared with normal weight (18.5 ≤ BMI < 25 kg/m2) (41 [47.7%] vs 39 [28.7%]; adjusted odds ratio [OR], 2.539; 95% confidence interval [CI], 1.389–4.642; P = 0.002). Furthermore, patients with obese were at even higher risk of postoperative severe AKI after controlling for confounding factors (adjusted OR: 3.705; 95% CI: 1.108–12.388; P = 0.033).ConclusionsOverweight is independently associated with an increased risk of postoperative severe AKI among patients receiving OLT. The association of BMI with severe AKI after OLT is J-shaped.
Highlights
Acute kidney injury (AKI) is a common postoperative complication of orthotopic liver transplantation (OLT)
Overweight is independently associated with an increased risk of postoperative severe AKI among patients receiving OLT
When compared with normal weight, patients with obese were at even higher risk of postoperative severe AKI, independent of traditional risk factors. (Table 3)
Summary
Acute kidney injury (AKI) is a common postoperative complication of orthotopic liver transplantation (OLT). The objective of our study was to determine whether overweight (BMI [Body Mass Index] ≥ 25 kg/m2) is associated with an increased risk of AKI after OLT. Acute kidney injury (AKI) is a common postoperative complication of orthotopic liver transplantation (OLT), with varying occurrence ranging from 5 to 94% [1]. This extreme variability may be due to the absence of a uniform definition of AKI and rapid improvement of surgical technique and perioperative management over the past few decades. As the etiology of AKI after OLT are multifactorial and not well understood, timely preventive therapy or medical interventions performed during the initiation phase of AKI can minimize the extent of injury and promote renal recovery, the cornerstone for reducing the development of AKI after OLT is early recognition of high-risk patients alongside active perioperative management
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