Association of Non-Alcoholic Fatty Liver Disease with Cardiac Arrhythmias and Cardiac Conduction Defects: A Review of the Literature

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition that affects a significant portion of the global population and imposes a heavy clinical and economic burden. Recent studies have provided substantial evidence linking NAFLD to cardiac electrical abnormalities, including atrial and ventricular arrhythmias, heart blocks, conduction delays, and ECG changes. These cardiac electrical disturbances play a significant role in cardiac diseases that are the leading cause of death in NAFLD patients. This paper aims to provide an update on the proposed mechanisms underlying arrhythmogenesis in NAFLD and summarize the latest research findings in this field. Managing NAFLD requires a comprehensive approach that includes treating the underlying liver condition and regular ECG monitoring to detect and address any potential cardiac complications. Meta-analyses are recommended for future research further to elucidate the association between NAFLD and cardiac arrhythmias. Understanding and effectively managing the cardiac implications of NAFLD will contribute to improved patient care and outcomes.