Abstract
Background & aimsNasal obstruction caused by nasal septal deviation is very bothersome and, therefore, can affect the patient’s emotional state. However, little is known about the effect of nasal septal deviation (NSD) on the neuropsychiatric aspects of patients. Therefore, this study aims to verify the higher incidence of anxiety, depression, and migraine in patients diagnosed with NSD compared to general populations using big data.MethodsThis retrospective cohort study collected subjects from the Korean National Health Insurance Service (NHIS) database. Adjustments were made to minimize the confounding of variables for age, sex, residence type, income levels, hypertension, diabetes, dyslipidemia, rhinitis, and chronic rhinosinusitis between the two groups. The primary endpoint of this study was newly diagnosed anxiety, depression, and migraine between January 2009 and December 2018. Kaplan-Meier survival curves, logarithmic rank test, and Cox proportional regression test were used for statistical analysis.ResultsAmong a total of 135,769 subjects in the NHIS database, 48,495 patients with NSD (NSD group) and 54,475 control subjects (control group) were selected. Patients with NSD had an increased risk of anxiety, depression, and migraine compared to the control group. In the NSD group, the adjusted hazard ratios (HR) were 1.236 (95% CI, 1.198–1.276) for anxiety, 1.289 (95% CI, 1.238–1.343) for depression, and 1.251 (95% CI, 1.214–1.290) for migraine.ConclusionNSD is associated with a higher incidence of anxiety, depression, and migraine. Therefore, it is suggested that physicians carefully consider psychoneurological distress and employ therapeutic strategies to minimize these conditions.
Highlights
Nasal septal deviation (NSD) is one of the most prevalent upper airway diseases in an otorhinolaryngology clinic, causing nasal airway obstruction [1]
In the nasal septal deviation (NSD) group, the adjusted hazard ratios (HR) were 1.236 for anxiety, 1.289 for depression, and 1.251 for migraine
NSD is associated with a higher incidence of anxiety, depression, and migraine
Summary
Nasal septal deviation (NSD) is one of the most prevalent upper airway diseases in an otorhinolaryngology clinic, causing nasal airway obstruction [1] This common nasal pathology affects the quality of life (QOL) due to its rhinologic symptoms [2, 3]. Previous articles have reported non-rhinologic manifestations accompanying NSD, such as facial pain, sleep problems, and loss of productivity [4, 5]. Due to these effects on overall QOL, it can be assumed that NSD is associated with neuropsychological disorders such as anxiety, depression, and migraine. This study aims to verify the higher incidence of anxiety, depression, and migraine in patients diagnosed with NSD compared to general populations using big data
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