Association of Metabolically Healthy and Unhealthy Obesity Phenotypes with Oxidative Stress Parameters and Telomere Length in Healthy Young Adult Men. Analysis of the MAGNETIC Study.

Mateusz Lejawa,Natalia Pawlas,Tadeusz Osadnik,Kamila Osadnik

doi:10.3390/antiox10010093

Mateusz Lejawa, Natalia Pawlas + Show 2 more

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https://doi.org/10.3390/antiox10010093

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Abstract

Obesity is a significant factor related to metabolic disturbances that can lead to metabolic syndrome (MetS). Metabolic dysregulation causes oxidative stress, which affects telomere structure. The current study aimed to evaluate the relationships between telomere length, oxidative stress and the metabolically healthy and unhealthy phenotypes in healthy young men. Ninety-eight participants were included in the study (49 healthy slim and 49 obese patients). Study participants were divided into three subgroups according to body mass index and metabolic health. Selected oxidative stress markers were measured in serum. Relative telomere length (rTL) was measured using quantitative polymerase chain reaction. The analysis showed associations between laboratory markers, oxidative stress markers and rTL in metabolically healthy and unhealthy participants. Total oxidation status (TOS), total antioxidant capacity (TAC) and rTL were significantly connected with metabolically unhealthy obesity. TAC was associated with metabolically healthy obesity. Telomeres shorten in patients with metabolic dysregulation related to oxidative stress and obesity linked to MetS. Further studies among young metabolically healthy and unhealthy individuals are needed to determine the pathways related to metabolic disturbances that cause oxidative stress that leads to MetS.

Highlights

Obesity is one of the most common epidemics today and has become one of the greatest health problems of this century [1]
metabolically unhealthy obese (MUO) was associated with higher body mass index (BMI), Waist-to-Hip Ratio (WHR), visceral adipose index (VAI), systolic blood pressure (SBP), diastolic blood pressure (DBP), Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TG, Apolipoprotein B (apoB), glucose, HbA1c, uric acid, GGT, high-sensitivity C-reactive protein (hsCRP), fibrinogen, and liver enzymes (ALT, aspartate transaminase (AST), lactate dehydrogenase (LDH)) and lower HDL, HDL%, apolipoprotein A1 (apoA1), bilirubin, and CuZnSOD
We found that shorter Telomere length (TL) was not associated directly with obesity because we did not observe any significant difference in TL between groups that differed in terms of BMI (MHNW vs. metabolically healthy obese (MHO))

Summary

Introduction

Obesity is one of the most common epidemics today and has become one of the greatest health problems of this century [1]. Suboptimal body weight is a key risk factor in diseases such as type 2 diabetes, dyslipidemia, hypertension and various types of cancer [3,4]. Obesity and MetS are associated with morbidity and mortality mainly due to cardiovascular diseases (CVDs), as well as with abnormal health conditions [6]. There are some that, despite excessive body weight, show no signs of metabolic disorders. Such people are called metabolically healthy obese (MHO). MHO individuals are free from obesity-related metabolic disorders, have a lower risk of developing CVDs and show lower mortality than metabolically unhealthy obese (MUO) individuals [7]

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