Abstract
Associations of restriction fragment length polymorphism in porcine attractin (ATRN) gene with average daily gain (ADG), live weight (LWT) and back fat thickness (BFT) were studied with one exotic composition population (Xianghuang) and three local breeds (Ningxing, Shaziling and Daweizi) in China. Two types of alleles were detected; one with the band size of 700 bp (A) and the other with the band size of 450 and 250 bp (B), and their genotypes were classified as AA, AB and BB. Polymorphisms were observed in the exotic breed, but not in the three local breeds. Individuals with the genotype BB showed larger ADG and LWT than those with AA in Xianghuang population (p<0.05). The breed specific effects of the porcine attractin gene in this study implied that identification of the polymorphisms and determination of genetic effects on phenotypes should be performed in the target populations. (Asian-Aust. J. Anim. Sci. 2005. Vol 18, No. 10 : 1383-1386)
Highlights
Tang and Duke-Kohan, 2002).It has been reported that the mutations in ATRN locusMahogany gene was characterized as a recessive coat suppressed the pleiotropic phenotypes color mutation in mouse (Lane and Green, 1960), and its of the agouti-lethal-yellow mutant (Miller et al, 1997; high homology with human attractin gene led to another Dinulescu et al, 1998)
While the expressed in the ventromedial hypothalamic nucleus, a human and rat ATRN genes encode membrane- and region intimately involved in the regulation of body weight secreted-type proteins, the hamster and mouse genes encode and feeding, and suggested that the mahogany locus could only membrane-type protein (Kuramoto et al, 2002)
Such a wide distribution in central nervous system (CNS) suggested a locomotor activity under normal food intake. These results broad spectrum of physiological functions for the ATRN implied the associations of ATRN locus products with gene product including immune system regulation, body growth and carcass composition of animals, especially weight control, pigmentation, myelination, and tumor focusing on the mouse, rat, hamster and human
Summary
Mahogany gene was characterized as a recessive coat suppressed the pleiotropic phenotypes (including obesity) color mutation in mouse (Lane and Green, 1960), and its of the agouti-lethal-yellow mutant (Miller et al, 1997; high homology with human attractin gene led to another Dinulescu et al, 1998). Gunn et al (2001) found that mRNAs were found in central nervous system (CNS) such mice carrying a homozygous mutant genotype led to as limbic structures, brainstem, cerebellum, spinal cord, and reduced body weight, reduced adiposity, and increased hypothalamus Such a wide distribution in CNS suggested a locomotor activity under normal food intake. These results broad spectrum of physiological functions for the ATRN implied the associations of ATRN locus products with gene product including immune system regulation, body growth and carcass composition of animals, especially weight control, pigmentation, myelination, and tumor focusing on the mouse, rat, hamster and human. Genotyping was conducted on 129 pigs, and back fat KIM ET AL
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