Abstract
Breast cancer is the one of the most frequent neoplasm in women. In the last decades, detection of disease in earlier clinical stages has improved prognosis, however five-year disease-free survival still remains at about 72%. For this reason, continuing efforts to establish reliable prognostic markers are made. The presence of lymph node metastasis is one of the most important prognostic factors in breast cancer. Studies show that D2-40 immuno-stain demonstrated a significant higher detection of LVI as compared with routine H&E staining in early breast cancer. LVI is associated with axillary lymph node metastases and a long-term prognostic factor. A precise identification of LVI would have a strong clinical impact for breast cancer patients. In this study, we aim to demonstrated.
 LVI as a significant predictor of poor prognosis in patients with lymph node- negative patients with primary invasive breast cancer and its association with other known parameters such as tumour size, tumour grade, nodal metastasis and age.
Highlights
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide [1]
A total of 60 cases of invasive breast carcinomas were included in the study
Lympho-vascular invasion was analysed by D2-40 immuno-stain and was correlated with other prognostic factors
Summary
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide [1]. Breast carcinoma has been extensively studied upon and with the availability of vast evidence based data and literature various treatment modalities have been introduced to treat this life threatening disease. Incidence rates are higher in the West, the highest burden for breast cancer is in middle-income countries [2]. Majority of the breast carcinomas are usually asymptomatic and the usual mode of presentation is an incidental palpable lump or pain and rarely, they present with nipple discharge and skin changes [3]. Breast carcinomas have varying levels of invasion and aggressiveness irrespective of the duration of presentation. Even though extensive screening programs and clinical tests are available for early detection of this disease, there is higher morbidity and mortality rates of breast cancer in developing countries due to socioeconomic dependence and late diagnosis [4]. There is a lack of selfawareness of this life threatening malignancy in our country
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