Association of Iron Profile with Type 2 Diabetes Mellitus:Review

Abstract

This minireview assesses the correlation between iron profile levels and type 2 diabetes mellitus. Iron, ferritin, transferrin saturation, and total iron-binding capacity (TIBC) are examples of iron profiles. Every study included in this review shows that type 2 diabetics' blood serum has less iron overall and less iron-binding capacity. Conversely, the same studies' findings showed that individuals with type 2 diabetes had higher levels of ferritin in their blood serum. In terms of transferrin (iron) saturation, a number of studies show that it is rising, while a smaller number shows that it is falling in the blood serum of those who have type 2 diabetes. These investigations led to the conclusion that there is substantial evidence linking the iron profile to type 2 diabetic mellitus (T2DM). Reduced transferrin levels are connected to a lower risk of Type 2 Diabetes Mellitus, but higher serum iron, ferritin, and transferrin saturation are associated with an increased risk. There is also genetic evidence that links elevated systemic iron status to a higher risk of type 2 diabetes.