Abstract
BackgroundThis meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa).MethodsAssociation investigations were identified and included from the Embase, Cochrane Library and PubMed databases on March 1, 2018, and eligible investigations were analyzed by meta-analysis. Odds ratios (OR) were used to express the dichotomous data, and the 95% confidence intervals (CI) were also calculated.ResultsIn this meta-analysis, we found that the AA genotype of HIF1α 1790G/A was positively associated with the risk of RCC in overall populations, Caucasians, but not for Asians. G allele and GG genotype were not associated with the susceptibility of RCC in overall populations, Caucasians, and Asians. The G allele was negatively associated with PCa susceptibility in overall populations, Asians, but not for Caucasians. GG genotype was negatively associated with PCa susceptibility in Asians, but not for overall populations and Caucasians. HIF1α 1790G/A AA genotype was not associated with PCa susceptibility in overall populations of Caucasians or Asians.ConclusionAA genotype of HIF1α 1790G/A was positively associated with RCC risk in overall populations and Caucasians. Furthermore, the G allele was negatively associated with prostate cancer susceptibility in overall populations, Asians, and GG genotype was negatively associated with PCa susceptibility in Asians.
Highlights
This meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa)
Association of the HIF1α 1790G/A gene polymorphism with RCC susceptibility In this meta-analysis, we found that the AA genotype of HIF1α 1790G/A was positively associated with RCC risk in overall populations (OR = 3.09, 95% confidence intervals (CI): 1.38–6.92, P = 0.006; Fig. 1 and Table 2) and Caucasians, but not for Asians
G allele and GG genotype were not associated with RCC risk in overall populations (G: Odds ratios (OR) = 0.65, 95% CI: 0.26–1.67, P = 0.38; GG: OR = 0.63, 95% CI: 0.20–2.03, P = 0.44; Fig. 1 and Table 2), Caucasians, or Asians
Summary
This meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa). During hypoxia, reduced oxygen availability can inhibit these HIF hydroxylase enzymes, and lead to HIF1α protein accumulation, which may translocate to the cell nucleus, bind to the HIF1β, and. Given the importance of HIF signaling in disease, there is considerable interest in developing strategies to modulate HIF1α activity and to induce downstream signaling events. The available evidence is inadequate due to inconsistencies between studies and an overall lack of data. This meta-analysis was performed to investigate whether the HIF1α 1790G/A (rs11549467) gene polymorphism is associated with RCC, PCa susceptibility
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