Association of hyperuricemia with ischemic stroke in adult population

Abstract

Background: Stroke is the second most prevalent cause of dementia, the third biggest cause of mortality, and the top cause of disability globally. In addition to the conventionally recognized risk factors including smoking, diabetes, hypertension, ischemic heart disease, etc. Recent research on acute ischemic stroke has identified fresh risk variables, such as blood calcium, uric acid, homocysteine, and albumin levels. Hyperuricemia is frequently seen in patients with vascular risk factors and either directly or indirectly through the conventional risk factors.
 Study: Case control study of 200 patients, 100 patients with stroke and 100 unmatched controls were accessed for vascular risk factor and hyperuricemia and odds ratio was calculated.
 Results: Out of 100 patients in the case group, 25 (25%) and 75 (75%) had and did not have hyperuricemia. Whereas, out of 100 patients in the control group, 07 (7%) and 9 3 (93%) had and did not have hyperuricemia. The P-value was 0.001. Odds ratio was 4.42.
 Conclusion: Hyperuricemia is linked positively to occurrence of ischemic stroke as evidenced by the positive odds ratio, further studies need to be done whether uric acid lowering therapy is useful in preventing stroke or reducing mortality.