Abstract
Type-1 diabetes (T1D), an autoimmune disease, significantly impacts global health, with varying prevalence across different geographies. This study investigates the association of specific Human Leukocyte Antigen (HLA) Class II alleles, namely DQB1*03:02, DQB1*06:02, and DRB1*04:01, with T1D in the Khyber Pakhtunkhwa (KP) population of Pakistan. Conducted as a 1:1 matched case-control study, this research involved 33 T1D patients and an equal number of age- and gender-matched healthy controls. Our findings reveal a weak association of alleles DRB1*04:01 and DQB1*03:02 with T1D (OR = 2.065 and 1.393, respectively, p > 0.05). DQB1*06:02 allele, which is considered to have a protective effect against T1D was more prevalent in control as compared to cases (93.9% vs 90.9%), however, the association was non-significant (OR 0.645, p > 0.05). These insights contribute to understanding genetic influences on T1D in the KP region and underscore the need for further research with larger, diverse cohorts to refine the genetic markers of T1D risk and protection
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
