Abstract
Atopy is characterized by the production of a high level of IgE in response to common allergens. We examined the RsaI-in2 polymorphism of the FceRI-β gene and its association with atopic asthma and comorbidity. The study population included 77 atopic asthmatics and 77 non-atopic, non-allergic and non-asthmatic controls. Atopic asthma was confirmed by the skin prick test and by IgE and interleukin IL-4 levels. RsaI-in2 polymorphism was determined by RFLP-PCR using the RsaI enzyme. A significant correlation was found between genotype BB and sensitization to house dust mites in the asthmatic subjects (p = 0.000). Results also reveal significant allele sharing in the subjects affected by eczema (p = 0.000) and allergic rhinitis (p = 0.01) during childhood. Furthermore, the subjects with heterozygous AB and homozygous BB genotypes displayed significant IgE levels > 1000 UI mL-1. IL-4 levels were also > 1000 pmol/ml for RsaI-in2 polymorphism genotype BB. Our findings show a strong association between genotype BB and the incidence of eczema and allergic rhinitis in childhood as well as increased IgE and IL-4 levels.
Highlights
Asthma is a major public health problem affecting millions people worldwide (Report TGA, 2014)
The biological parameters reveal that the subjects with atopic asthma displayed significantly (p
Our results showed a highly significant difference between the asthmatic and control subjects, with a 59.74% of patients having eczema and 58.44% suffering from allergic rhinitis as compared to the controls (Table 1)
Summary
Asthma is a major public health problem affecting millions people worldwide (Report TGA, 2014). Asthma is set to become one of the world’s most prevalent chronic diseases (Licari et al, 2017). Asthma occurs at all ages (Baxter et al, 2017; Terry et al, 2017). The elderly population (>65 years of age) account for 13% of the U.S population (Baxter et al, 2017; Terry et al, 2017). This age group will account for 25% of the population by 2050 (Hanania et al, 2011). There is a known link between the early presence of atopy and the later development of asthma (Fiuza et al, 2017)
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