Abstract
Objective: The aim of this study was to determine the association of HbA1c with coronary artery disease (CAD) in non-diabetic patients undergoing coronary artery angiography. Methods: This cross-sectional study was conducted on 265 individuals referred to an educational heart hospital affiliated with Urmia University of Medical Sciences, north of Iran. Participants were selected through a convenient sampling method. Patients underwent angiography, and CAD disease severity for them was computed using a GSS score. The association of HbA1c and other variables on CAD disease severity was investigated. Results: A total of 265 non-diabetic diabetic patients with a mean age of 59.36 years were investigated. The mean body mass index was 26.42 kg/m2 and the mean left ventricular ejection fraction (LVEF) was 48.62%. The mean score of the Geriatric Scoring System in patients was 31.28. As the GSS score increased, HbA1c was significantly increased as well. HbA1c had an appropriate value in the diagnosis of severe CAD, and the best cutoff point for this assessment was 6.15%. In addition, HbA1c had an appropriate value in the diagnosis of mild CAD, but cigarette use and hypertension had no significant effect on this association. Conclusion: HbA1c with cutoff points mentioned was an appropriate factor to determine the severity of CAD in non-diabetic patients; therefore, it is recommended to use that to determine disease severity, and in patients with high levels of HbA1c, close follow-up and treatment need to be done to decrease the complications and mortality.
Published Version
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