Association of HbA1c with Lipid profiles in patients with type 2 diabetes mellitus

Abstract

Background: Patients with type 2 diabetes have an increased prevalence of dyslipidemia. A timely intervention to normalize circulating lipids could reduce the chances of cardiovascular diseases. Glycated hemoglobin (HbA1c) is the indicator of glycemic status over long term. This study was conducted to find the association between HbA1c and lipid profiles in patients with type 2 diabetes mellitus. Methods: A confirmed 52 cases with type 2 diabetic mellitus were enrolled in the study. Fasting blood samples were collected and different lipid fractions along with fasting blood glucose were estimated by enzymatic method. LDL-C and VLDL-C were determined by Friedewald’s formula Glycated hemoglobin (HbA1c) with radioimmunoassay. Results: HbA1c has significant positive correlation (p<0.016-0.001) with FBG, TC, TG, LDL-C and LDL-C/HDL-C. Among the lipid components, TC has significant positive correlations (p<0.007-0.001) with TG, LDL-C,TC/HDL-C,TG/HDL-C and LDL-C/HDL-C, where as TG has significant positive correlations (p<0.001) with TC/HDL-C and TG/HDL-C.HDL-C has significant negative correlations (p<0.002-0.0001) with TC/HDL-C, TG/HDL-C and LDL-C/HDL-C whereas, LDL-C has significant positive correlations (p<0.001) with TC/HDL-C and LDL-C/HDL-C. VLDL-C has significant positive correlation (p<0.001) with HDL-C and significant negative correlation (p<0.002) with TG mg/dl. Lastly, TC/HDL has significant positive correlation (p<0.001) with TG/HDL-C and LDL-C/HDL-C. Conclusion: Significant positive correlation of HbA1c with lipid profiles suggested that HbA1c can also be used as predictor of Dyslipidemia in addition to as a glycemic control parameter.