Association of HBA1C level with extent of Acute Myocardial Infarction and Short Term Mortality

Abstract

ABSTRACT Objectives: To determine the prognostic value of HBA1C level with extent of acute Myocardial Infarction (MI) and short-term mortality in patients without known Diabetes. MATERIAL AND METHODS The prospective cohort, department of Cardiology at Liaquat University Hospital Hyderabad during the period of one year from February 2020 January 2021. All the patients aged 20-75 years, both genders with acute MI (STEMI and NSTEMI) were included. All the patients diagnosed for MI according to ECG and serum cardiac biomarkers such as Troponin-T and Troponin-I. Blood sample were taken from all the cases for assessment of HbA1c level. Echocardiography was done and categorized according to the left ventricle ejection fraction. Short term mortality was assessed in all patients. All the data was recorded in the proforma for the purpose of analysis. After collection of data the analysis was conducted by using SPSS version 22.0. Results: Total 377 patients of acute MI were studied; their mean age was 50.42+11.71 years. Out of all study subjects’ males were in majority 83.0% and females were 17.0%. Out of all 59.4% had HbA1c level <5.5 and 40.6% had HbA1c was <6.5. Most of the study subjects 62.9% had left ventricular ejection fraction was <40%. Majority of the cases 77.7% had STEMI and NSTEMI was seen in 22.3% of the cases. Overall short-term mortality (30 days) was found 14.3%. In this study short term mortality (30 days) was statistically significant according to the gender, HbA1c, left ventricular ejection fraction and types of the MI, P-<0.05). Conclusion: As pers study conclusion overall short-term mortality (30 days) was 14.3%. Higher HbA1c was observed to be a potential indicator for short term mortality among patients of acute coronary syndrome (ACS) and a predictor for short-term mortality in ACS patients without known DM and without DM Key words: Acute MI, 30 days mortality, Hba1c