Abstract
Genetic polymorphism was hypothesized to be reason of variation in prostate cancer incidence among different racial group. Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent. A meta-analysis including 8 articles with 711 cases and 1122 controls for GSTT1 and 1098 cases and 1588 controls for GSTM1 was performed. Significantly increased prostate cancer risk was found among subjects carrying GSTM1 null genotype (odds ratio (OR) = 1.403; 95% confidence interval (CI) = 1.088 - 1.808) but not among subjects carrying GSTT1 deletion genotype (OR = 0.959; 95%CI = 0.709 - 1.297). When stratified by country, the null genotype of GSTT1 neither increased nor decreased prostate cancer risk significantly in China (OR = 1.355; 95%CI = 0.895 - 2.049), Japan (OR = 0.812; 95%CI = 0.545 - 1.211), and Korea (OR = 1.056; 95%CI = 0.727 - 1.534). While significant association of elevated prostate cancer risk with GSTM1 deletion were found in China (OR = 1.665; 95%CI = 1.324 - .094) and Korea (OR = 1.914; 95%CI = 1.311 - 2.793) but not in Japan (OR = 0.980; 95%CI = 0.726 - 1.321). In summary, this meta-analysis suggested that the null genotype of GSTM1 rather than GSTT1 may be involved in the etiology of prostate cancer in Asian population.
Highlights
Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancerrelated deaths in the western male population [1]
Significantly increased prostate cancer risk was found among subjects carrying Glutathione S-transferase M1 (GSTM1) null genotype (odds ratio (OR) = 1.403; 95% confidence interval (CI) = 1.088 − 1.808) but not among subjects carrying Glutathione S-transferase T1 (GSTT1) deletion genotype (OR = 0.959; 95%CI = 0.709 − 1.297)
While significant association of elevated prostate cancer risk with GSTM1 deletion were found in China (OR = 1.665; 95%CI = 1.324 − .094) and Korea (OR = 1.914; 95%CI = 1.311 − 2.793) but not in Japan (OR = 0.980; 95%CI = 0.726 − 1.321)
Summary
Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancerrelated deaths in the western male population [1]. In Asian, especially in china with the largest population in world, the detection rate and incidence of prostate cancer is increasing rapidly due to the extension of life expectancy, the change of lifestyles and the improvement of clinical skills [2]. Individuals of Asian descent who live in diverse environment around the world still have low risk of developing prostate cancer. Among the GSTs isoforms, the polymorphism of Glutathione S-transferase T1 and M1 (GSTT1 and GSTM1) to prostate cancer risk has become a research focus in scientific community and has drawn increasing attention. Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent
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