Abstract
ObjectivesTo comprehensively evaluate the association of ERCC1 C8092A and ERCC2 Lys751Gln polymorphisms with the risk of glioma.MethodsPotential studies were searched and selected through the Pubmed/MEDLINE, EMBASE, the China National Knowledge Infrastructure (CNKI) platforms, WanFang and VIP database up to June 2013. Two investigators independently reviewed full text and included studies met inclusion criteria. Combined odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in a fixed-effects model or a random-effects model according to results of heterogeneity test. All analyses were performed by Revman 5.2 and Stata 10.0 software.ResultsA total of 10 studies were included in our meta-analysis, including 3,580 glioma patients and 4,728 controls. Overall, ERCC1 C8092A polymorphism was associated with the risk of glioma (AA vs. CC: OR = 1.29, 95%CI: 1.07–1.55, P = 0.01; recessive model: OR = 1.29; 95% CI: 1.07–1.55, P = 0.01). When stratified by ethnicity, significant association was only observed in the Chinese population (AA vs. CC: OR = 1.37, 95%CI: 1.03–1.81, P = 0.03; recessive model: OR = 1.34; 95% CI: 1.02–1.75, P = 0.04). For ERCC2 Lys751Gln polymorphism, no significant association was found between ERCC2 Lys751Gln polymorphism and the risk of glioma in different genetic models. A significant association of ERCC2 Lys751Gln polymorphism with the risk of glioma was identified in the Caucasian population under recessive model (OR = 0.87; 95% CI: 0.78–0.98, P = 0.02), but not in the Chinese population.ConclusionThis meta-analysis suggested that the AA genotype of ERCC1 C8092A polymorphism might increase the susceptibility of glioma in the Chinese population. And the TT genotype of ERCC2 Lys751Gln polymorphism may decrease the risk of glioma in the Caucasian population. But the small number of studies and moderate methodological quality require cautious interpretation of the study results.
Highlights
Glioma is one of the most common brain tumors, accounting for approximately 80% of all brain tumors [1]
excision repair cross-complementing group 1 (ERCC1) C8092A polymorphism was associated with the risk of glioma (AA vs. CC: odds ratios (ORs) = 1.29, 95%confidence interval (CI): 1.07–1.55, P = 0.01; recessive model: OR = 1.29; 95% confidence intervals (95% CIs): 1.07–1.55, P = 0.01)
Significant association was only observed in the Chinese population (AA vs. CC: OR = 1.37, 95%CI: 1.03–1.81, P = 0.03; recessive model: OR = 1.34; 95% CI: 1.02–1.75, P = 0.04)
Summary
Glioma is one of the most common brain tumors, accounting for approximately 80% of all brain tumors [1]. In a multi-center cross-sectional study in China, it is estimated that the agestandardized prevalence of primary brain tumor is 22.52 per. Of 272 newly diagnosed brain tumors, glioma accounted for 29.78% [2]. The prevalence of glioma is relatively lower than other cancers, survival rates of glioma patients is still poor, especially the 5 year survival rate of glioblastoma case, less than 3% [3,4,5]. The development and progression of glioma are determined by genetic and environmental factors. There are several confirmed environmental risk factors, including ionizing radiation, ultraviolet (UV) rays, diet and doi:10.1371/journal.pone.0095966.g001
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