Abstract
Objective: : Several previous studies have reported the role variant of ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms in the risk of glioma, but the results of these studies are inconsistent. Therefore, we aimed to conduct a meta-analysis to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 on the risk of glioma. Methods: A comprehensive research was conducted through the databases of Pubmed, EMBASE and the China National Knowledge Infrastructure (CNKI) platforms until June 1, 2014, including 14 eligible case-control studies. Results: Our meta-analysis found that ERCC1 rs3212986 AA genotype was significantly associated with increased risk of glioma compared with CC genotype, and the pooled OR (95%CI) was 1.29(1.07-1.55). By subgroup analysis, ERCC1 rs3212986 AA genotype was found to be significantly correlated with increased glioma risk in Chinese population (OR=1.37, 95%CI=1.07, 1.55), Similarly, we found that ERCC2 rs13181 GT and TT genotypes were significantly associated with increased risk of glioma in Chinese population, with ORs(95%CI) of 1.47(1.17-1.85) and 1.50(1.02-2.22). But ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms had no significant association with glioma risk in Caucasian populations. By begg’s funnel plot, we found that no publication bias was existed in this meta-analysis. Conclusion: Our meta-analysis suggested that ERCC1 rs3212986 and ERCC2 rs13181 polymorphism play an important risk factor for brain tumor development in Chinese population, but no association in Caucasian populations.
Highlights
Gliomas are the most common occurring type of brain tumors worldwide, accounting for approximately 80% of all malignant brain tumors.[1]
Characteristics of eligible publications: Our comprehensive literature search identified a total of 57 studies for Excision repair cross complementation group 1 (ERCC1) rs3212986 and ERCC2 rs13181 based on their titles
Eight studies reported the association between ERCC1 rs3212986 polymorphism and glioma risk, including 3008 glioma cases and 4319 controls (Table-I).[11,12,13,14,15,16,17,18 11] studies reported the association between ERCC2 Lys751Gln polymorphism and glioma risk, including 3456 glioma cases and 4957 controls (Table-II).[12,13,14,15,19,20,21,22,23,24,25]
Summary
Gliomas are the most common occurring type of brain tumors worldwide, accounting for approximately 80% of all malignant brain tumors.[1]. Previous studies reported that mutations of many genes can affect the risk of glioma.[7,8,9]
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