Association of ENPP1 (K121Q rs 1044498) and TCF7L2 (C/T rs7903146) Gene Polymorphisms with Type2 Diabetes in Zanjan population (Northwest, Iran)

Sanaz Mahmazi,Abdolreza Esmaeilzadeh,Pourandokht Golbon

doi:10.30699/jambs.26.118.9

Abstract

Association of ENPP1 (K121Q rs 1044498) and TCF7L2 (C/T rs7903146) Gene Polymorphisms with Type2 Diabetes in Zanjan population (Northwest, Iran)

Highlights

Type 2 Diabetes (T2D) is a progressive multifactorial disease influenced by environmental and genetic factors and can be controlled or prevented if genetic factors are identified, and by changing the environment and lifestyle [1]
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) 121Q (CC) genotype was significantly higher in T2D comparing to controls (OR;1.61, 95% CI;1.02-2.55, P=0.02) and a significant association between the frequency of C allele and T2D was observed (OR;1.339, 95%CI;1.041.72, P=0.012)
TT genotype of Transcription factor-7-like 2 (TCF7L2) C>T rs7903146 was significantly higher in T2D patients (OR;0.67, 95% CI;0.49-0.98, P=0.02), but the T allele could not significantly affect the risk for T2D in our population

Summary

Introduction

Type 2 Diabetes (T2D) is a progressive multifactorial disease influenced by environmental and genetic factors and can be controlled or prevented if genetic factors are identified, and by changing the environment and lifestyle [1]. The main factor controlling and regulating blood sugar is the insulin hormone, which is secreted from pancreatic β cells and acts on cells in different tissues, helping to match the glucose uptake by them, and glucose increase is observed when glucose uptake by cells becomes difficult [2]. Changes in all genetic factors that play a role in regulating the function of the pancreatic β cells in the pathway for the production and secretion of insulin are good candidates for examination as a cause of diabetes [4]. The study of genetic and environmental factors that regulate the response of cells to insulin are important because they lead to insulin resistance and cause T2D [5]. Determining the genes involved in the onset of diabetes could help define the pathway of disorder leading to diabetes; in that case, appropriate and effective treatment strategies can be identified, and even preventive strategies can be developed [1]

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