Abstract
Background: GDM is a condition where there is an onset of carbohydrate intolerance during pregnancy. In this condition many changes will take place in carbohydrate metabolism and other metabolic pathways especially in lipid metabolism. These metabolic changes associated with insulin resistance and dyslipidemia. We have aim to study the association between dyslipidemia and glycated haemoglobin. Materials and Methods: The study was conducted in 80 pregnant women of rural population of Puducherry in two groups. Group 1 includes 40 newly diagnosed GDM patients by DIPSI and Group II with 40 normal pregnant women, age group were between 20 to 40 years. Fasting blood glucose, 2-hour post glucose and lipid profile were estimated by auto analyzer. HbA1c was analysis by HPLC method. For comparisons of means student t-test was used to determine the significance between GDM and controls. Results: There was statistically significant difference in lipid profiles (P = 0.05), HDL (P = 0.04), VLDL (P = 0.00), LDL (P = 0.04) HDL (P = 0.04) in GDM groups. HbA1c (P = 0.02) levels were statistically significant with GDM pregnant women. There was no statically significant difference between FG (P = 0.23), TG (P = 0.30) and lipids profiles ratio levels in GDM. Conclusion: This study was found to be associations between lipids profiles and Gestational diabetes mellitus in GDM groups.
Highlights
3 ml of fasting serum samples and 1 ml of whole blood samples will be collected in Clinical Chemistry laboratory for the estimation of fasting glucose (GOD-POD method), 2-hour post glucose levels and HbA1c (HPLC method), Lipids profile was estimated by IFCC approved clinical chemistry analyzer
**Correlation is significant at the 0.01 level (2-tailed); *Correlation is significant at the 0.05 level (2-tailed). This present study has shown that TC (p = 0.05), LDL (p = 0.04), LDL (p = 0.04), VLDL (p = 0.00), these lipid profiles are higher and statistically significance in Gestational diabetes mellitus (GDM) groups
Our study shows dyslipidemia in gestational diabetes mellitus
Summary
Pregnancy is a state of mild insulin resistance which is attributed to increased maternal adiposity and insulin desensitizing effects of placental products such as human placental lactogen, estrogen and prolactin, which is normally counter balanced with increased beta-cell proliferation and production of insulin [3]. Those patients who have limited beta cell capacity for the compensation of pregnancy induced insulin resistance due to variations in the genes involved in insulin secretion and utilization of carbohydrates is likely to develop GDM [4]. In this present study we have to plan association of dyslipidemia and glycated haemoglobin
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