Abstract
Background Chronic kidney disease is a major microvascular complication of Diabetes Mellitus (DM) and may affect about one third of the patients. Based on the evidence that a proportion of patients may have reduced glomerular filtration rate (GFR) without increased albuminuria, it is recommended to evaluate both parameters. Furthermore, both of them are considered prognostic factors of renal and cardiovascular mortality. Hence, the evaluation of the possible association between dietary fat content and renal dysfunction assessed by GFR is also relevant.
Highlights
Chronic kidney disease is a major microvascular complication of Diabetes Mellitus (DM) and may affect about one third of the patients
Materials and methods In this prospective cohort study the usual diet of patients was assessed by a 3-day weighed diet record (WDR)
In multiple linear regression models, adjusting for age, gender, systolic blood pressure and 24-hour UAE, the eGFR decline per year was positively associated with the dietary trans fatty acid intake (% energy) (R2=0.074, b Standardized Coefficients=0.106, P=0.049)
Summary
Chronic kidney disease is a major microvascular complication of Diabetes Mellitus (DM) and may affect about one third of the patients. Based on the evidence that a proportion of patients may have reduced glomerular filtration rate (GFR) without increased albuminuria, it is recommended to evaluate both parameters. Both of them are considered prognostic factors of renal and cardiovascular mortality. The evaluation of the possible association between dietary fat content and renal dysfunction assessed by GFR is relevant
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