Abstract
Context: The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of β-cell function and metabolic effects of insulin in the liver. Objective: The objective of the study was to investigate whether common genetic variation within the FOXO1 gene encoding FOXO1A contributes to prediabetic phenotypes, such as insulin resistance or β-cell dysfunction, and to risk of type 2 diabetes. Design and Settings: Study I was a study enrolling thoroughly phenotyped subjects from Germany at increased risk for type 2 diabetes. Study II was a population-based study of Finnish men for the assessment of the prevalence of type 2 diabetes and metabolic syndrome. Participants: Study I included 941 nondiabetic subjects (353 males, 588 females, aged 39 ± 1 yr, body mass index 29.2 ± 0.3 kg/m2). Study II included 5957 middle-aged men (870 type 2 diabetic and 5087 nondiabetic subjects). Interventions: Genotyping for 10 single-nucleotide polymorphisms (SNPs) covering 100% of common genetic variation ...
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