Abstract
ObjectiveMicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque.MethodsDuring January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed.ResultsPatients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001).ConclusionsThe serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis.
Highlights
MicroRNA is a well-known marker of atherosclerosis and a good predictor for future risk of cardiovascular events
Two groups were basically well-matched on separate index in baseline characteristics (Table 1)
We identified that coronary heart disease (CHD) group has increased serum miR-122
Summary
MicroRNA (miRNAs) is a well-known marker of atherosclerosis and a good predictor for future risk of cardiovascular events. Previous studies indicated that abnormal expression levels of plasma miRNAs is helpful for improving the discrimination of coronary heart disease (CHD) (Corsten et al, 2010; Li et al, 2017; Zhang et al, 2017). There is clear evidence that an independent relationship exists between plasma cholesterol levels and the risk for atherosclerotic lesion (Jensen et al, 2017). The concept that several miRNAs are potential indicators for lipid metabolism has expanded very quickly in recent decade (Cheng et al, 2017; Gadde & Rayner, 2016). How to cite this article Wang and Yu (2018), Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions.
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