Abstract
s / Pancreatology 14 (2014) S1eS129 S57 pancreatitis was induced by four hourly injections of caerulein [50 mg/kg/ dose] and in the high dose group by8 injections. Further, one groupof animals that received 4 injections was given a longer duration of injury by sacrificing this group at the 9th hour after the induction of pancreatitis by caerulein. The pancreatic tissue was processed for transmission electron microscopy. Results: The acinar cells of the pancreatitis groups revealed autophagosomes that contained cellular organelles, including mitochondria. The animals that received a higher dose had numerous cells showing a necrotic morphology, whereas the animals in the low dose group showed a predominantly apoptotic cell morphology. Conclusion: Dysfunctional organelles in the injured pancreatic acinar cells are degraded by macroautophagy that includes mitochondriae. The consequent energy deficit in the cells may lead to necrosis.
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