Abstract
BackgroundC5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter. The aim of the present study is to evaluate the association of the SNPs of C5L2 gene with coronary artery disease (CAD) in a Chinese population.MethodsWe examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5L2 gene for CAD using a case-control design. We determined the prevalence of C5L2 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.ResultsThere was significant difference in genotype distributions of rs2972607 and rs8112962 between CAD patients and control subjects. The rs2972607 was found to be associated with CAD in a dominant model (AA vs. AG + GG, P<0.001). Similarly, the rs8112962 was found to be associated with CAD in a dominant model (TT vs CT + CC, P=0.016). The difference remained statistically significant after multivariate adjustment (OR =1.401, 95% confidence interval [CI]:1.026~1.914, P=0.034; OR = 1.541, 95%CI:1.093~ 2.172, P=0.014; respectively).ConclusionThe results of this study indicate that both rs2972607 and rs8112962 of C5L2 gene are associated with CAD in a Han population of China.
Highlights
Coronary artery disease (CAD) is a chronic complexity inflammatory disease, which is an interaction between environmental factors and genetics background
We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR-like receptor 2 (C5L2) gene for coronary artery disease (CAD) using a case-control design
The rs2972607 was found to be associated with CAD in a dominant model (AA vs. AG + GG, P
Summary
Coronary artery disease (CAD) is a chronic complexity inflammatory disease, which is an interaction between environmental factors and genetics background. Studies showed that the estimation of Non-HDL cholesterol (Non-HDL), such as increased levels of triglyceride (TG), apolipoprotein B, and elevated fasting blood glucose (FBS) are important for the process of atherosclerosis, as well as CAD [3,4,5]. Anaphylatoxin and their receptors play key roles in the process of inflammatory. C5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). The aim of the present study is to evaluate the association of the SNPs of C5L2 gene with coronary artery disease (CAD) in a Chinese population
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