Abstract
BackgroundComplement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. However, There are unknown associations between the SNPs of C5aR1 gene and coronary artery disease (CAD).MethodsWe examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR1 gene for CAD using a case–control design, and determined the prevalence of C5aR1 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.ResultsThe rs10853784 was found to be associated with CAD in dominant model (CC vs TT + CT, P = 0.004). The difference remained statistically significant after multivariate adjustment (OR = 1.430, 95% CI: 1.087 ~ 1.882, P = 0.011). There was no significant difference in genotype distributions of rs4577202 and rs7250152 between CAD patients and control subjects. The frequency of the haplotype (A-T-C) was significantly higher in the CAD patients than in the controls (P = 0.035), and the haplotype (A-C-T) was significantly lower in the CAD patients than in the control subjects in Chinese Han population (P = 0.002).ConclusionThe results of this study indicate that rs10853784 of C5aR1 gene are associated with CAD in Han population of China, and A-C-T haplotypes may be protective genetic marker and the A-T-C may be risk genetic marker for CAD in Chinese Han population.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2054871241495194.
Highlights
Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases
C5aR is a member of the rhodopsin family of G protein-coupled receptors (GPCR) which is expressed at varying levels in different immune and non-immune cells [14,15,16,17]
coronary artery disease (CAD) patients (n = 505) and healthy control subjects (n = 469), the following variables were significantly different between the two groups: diabetes and drinking; the serum concentration of glucose, apo B and LP(a)
Summary
Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. C5a is a multifunctional protein, which promotes the recruitment and activation of neutrophils and monocytes [3] Pathological conditions such as sepsis and various immunoinflammatory disorders are accompanied by increases in circulating C5a [11,12,13]. C5L2, which resembles C5aR (58% homology) [12] was demonstrated to be a functional receptor of acylationstimulating protein (ASP), increased transport of glucose and esterification of fatty acids, leading to a net accumulation of TG stores influence the body’s susceptibility to CAD [21,22,23]
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