Abstract
Objective To investigate the distribution of CD14 promoter gene C-159T polymorphsim in patients with type 2 diabetes mellitus(T2DM)and to analyze the association of CDI4 polymorphisms with diabetic nephropathy (DN). Methods Genotypes of CD14 were typed in 308 T2DM patients and 145 normal controls by polymerase chain reaction restriction fragment length polymorphism. Results (1)The distribution of CD14 promoter gene C-159T polymorphsim revealed no significant difference between normal control group and T2DM group(P>0.05). The distributions between CC genotype and CT+TT genotypes existed statistically significant difference in CD14-159 between two subgroups with and without diabetic nephropathy (P<0.05). (2)At 10 and 20 years after the onset of DM, 13.3% and 23.4% of the patients developed into DN respectirely. CC genotype had higher risk than CT+TT genotypes to develop into DN. Conclusion The distribution of CD14 promoter gene C -159T polymorphism has no relation with T2DM. The CC genotype of the C-159T polymorphism of CD14 gene is a risk factor for diabetic nephropathy. Key words: CD14 promoter; Diabetic nephropathies; Polymorphism, single nucleotide; Lipopolysaccharidereceptor
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